Dysregulation of epigenetic mechanisms has been recognized to play a crucial role in
cancer development, but these mechanisms vary between sexes. Therefore, we focused on …

Objective We determined whether DNA methylation of repetitive elements (RE) is altered in
epithelial ovarian cancer (EOC) patient tumors and white blood cells (WBC), compared to …

Ovarian cancer (OC) is a relatively fatal female reproductive malignancy. Since the
underlying causes are uncertain, it brings us to believe that both genetic and external factors …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative
disorder in which patients carry premutation alleles of 55–200 CGG repeats in the FMR1 …

Exposure to metals alters gene expression, changes transcription rates or interferes with
DNA repair mechanisms. We tested a hypothesis to determine whether in vitro acute metal …

Arsenic, a carcinogen, is assumed to induce global DNA hypomethylation by consuming the
universal methyl donor S-adenosylmethionine (SAM) in the body. A previous study reported …

DNA methylation is a key epigenetic process which has been intimately associated with
gene regulation. In recent years growing evidence has associated DNA methylation status …

DNA methylation plays a crucial role in higher organisms. Coupling bisulfite treatment with
next generation sequencing enables the interrogation of 5-methylcytosine sites in the …

The global incidence of nonalcoholic fatty liver disease (NAFLD) is mounting incessantly,
and it is emerging as the most frequent cause of chronic and end stage liver disorders. It is …

Using pharmacological unmasking microarray, we identified promoter DNA methylation of
cysteine dioxygenase 1 (CDO1) gene in human cancer. In this study, we assessed the …