Genetic insights, disease mechanisms, and biological therapeutics for Waardenburg syndrome

S Huang, J Song, C He, X Cai, K Yuan, L Mei, Y Feng - Gene therapy, 2022 - nature.com
Waardenburg syndrome (WS), also known as auditory-pigmentary syndrome, is the most
common cause of syndromic hearing loss (HL), which accounts for approximately 2–5% of …

Noise‐induced hearing loss: updates on molecular targets and potential interventions

H Mao, Y Chen - Neural Plasticity, 2021 - Wiley Online Library
Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

Stem cell-based therapies in hearing loss

Z He, Y Ding, Y Mu, X Xu, W Kong, R Chai… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, neural stem cell transplantation has received widespread attention as a new
treatment method for supplementing specific cells damaged by disease, such as …

Novel nanoencapsulation technology and its potential role in bile acid‐based targeted gene delivery to the inner ear

T Foster, M Lewkowicz, C Quintas, CM Ionescu… - Small, 2023 - Wiley Online Library
Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in
particular the sensitive hair cells, can impact individuals for the rest of their lives. There are …

ROS‐Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells

L Zhang, Z Du, L He, W Liang, K Liu, S Gong - Neural Plasticity, 2022 - Wiley Online Library
Sensorineural hearing loss (SNHL) is one of the most common causes of disability
worldwide. Previous evidence suggests that reactive oxygen species (ROS) may play an …

Key signaling pathways regulate the development and survival of auditory hair cells

Y Liu, M Wei, X Mao, T Chen, P Lin, W Wang - Neural Plasticity, 2021 - Wiley Online Library
The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural
hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is …

TRIM71 reactivation enhances the mitotic and hair cell–forming potential of cochlear supporting cells

XJ Li, C Morgan, PT Nadar‐Ponniah, W Kolanus… - EMBO …, 2023 - embopress.org
Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting
cells have some capacity to regenerate hair cells. However, their regenerative potential …

Emerging roles of RNA-binding proteins in inner ear hair cell development and regeneration

DL Shi, XN Cheng, A Saquet, R Grifone - International Journal of …, 2022 - mdpi.com
RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level.
They play major roles in the tissue-and stage-specific expression of protein isoforms as well …

N-Acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss and attenuates hair cell death caused by ROS stress

X Bai, S Chen, K Xu, Y Jin, X Niu, L Xie… - Frontiers in Cell and …, 2021 - frontiersin.org
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world.
Increasing evidence of imbalance of oxidant–antioxidant were found in SSNHL patients …

The Physiological Function and Potential Role of the Ubiquitous Na+/H+ Exchanger Isoform 8 (NHE8): An Overview Data

C Bernardazzi, IA Sheikh, H Xu… - International Journal of …, 2022 - mdpi.com
The Na+/H+ exchanger transporters (NHE) play an important role in various biologic
processes including Na+ absorption, intracellular pH homeostasis, cell volume regulation …