Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

DNA methylation is an important epigenetic modification that is essential for various
developmental processes through regulating gene expression, genomic imprinting, and …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

The deposition of DNA methylation at promoters of transposons, X-linked genes, imprinted
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1
recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3) …

Background Prenatal exposure to ethanol (E t OH) reduces the expression of hypothalamic
proopiomelanocortin (POMC) gene, known to control various physiological functions …