[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

LE McCoubrey, A Favaron, A Awad, M Orlu… - Journal of Controlled …, 2023 - Elsevier
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

Trimethylamine-N-oxide pathway: a potential target for the treatment of MAFLD

X Li, J Hong, Y Wang, M Pei, L Wang… - Frontiers in Molecular …, 2021 - frontiersin.org
Trimethylamine-N-oxide (TMAO) is a molecular metabolite derived from the gut flora, which
has recently emerged as a candidate risk factor for metabolic dysfunction-associated fatty …

Human Adult Microbiota in a Static Colon Model: AhR Transcriptional Activity at the Crossroads of Host–Microbe Interaction

E Goya-Jorge, I Gonza, P Bondue, C Douny… - Foods, 2022 - mdpi.com
Functional symbiotic intestinal microbiota regulates immune defense and the metabolic
processing of xenobiotics in the host. The aryl hydrocarbon receptor (AhR) is one of the …

Development of an in vitro Model of Human Gut Microbiota for Screening the Reciprocal Interactions With Antibiotics, Drugs, and Xenobiotics

A El Houari, F Ecale, A Mercier, S Crapart… - Frontiers in …, 2022 - frontiersin.org
Altering the gut microbiota can negatively affect human health. Efforts may be sustained to
predict the intended or unintended effects of molecules not naturally produced or expected …

Development and validation of a LC-MS/MS technique for the analysis of short chain fatty acids in tissues and biological fluids without derivatisation using isotope …

S Saha, P Day-Walsh, E Shehata, PA Kroon - Molecules, 2021 - mdpi.com
The gut microbiota is critical to the maintenance of physiological homeostasis and as such is
implicated in a range of diseases such as colon cancer, ulcerative colitis, diabetes …

Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute‐responsive change in cell morphology

AM Michel, JM Borrero‐de Acuña… - Environmental …, 2022 - Wiley Online Library
Infections by the pathogenic gut bacterium Clostridioides difficile cause severe diarrhoeas
up to a toxic megacolon and are currently among the major causes of lethal bacterial …

Microbiomes in physiology: insights into 21st‐century global medical challenges

E Shehata, A Parker, T Suzuki, JR Swann… - Experimental …, 2022 - Wiley Online Library
New Findings What is the topic of this review? The role of the gut microbiome in physiology
and how it can be targeted as an effective strategy against two of the most important global …

Multi-omic analyses reveal bifidogenic effect and metabolomic shifts in healthy human cohort supplemented with a prebiotic dietary fiber blend

JW Kang, X Tang, CJ Walton, MJ Brown… - Frontiers in …, 2022 - frontiersin.org
Dietary fiber, a nutrient derived mainly from whole grains, vegetables, fruits, and legumes, is
known to confer a number of health benefits, yet most Americans consume less than half of …

Spontaneous and Microbiota‐Driven Degradation of Anthocyanins in an In Vitro Human Colon Model

E Shehata, P Day‐Walsh, L Kellingray… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope The consumption of dietary anthocyanins is associated with various health benefits.
However, anthocyanins are poorly bioavailable, and most ingested anthocyanins will enter …

[HTML][HTML] Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model

P Kwandee, S Somnuk, B Wanikorn… - Journal of Traditional …, 2023 - Elsevier
Triphala is a mixture of tree fruits obtained from Terminalia chebula, Terminalia bellerica,
and Phyllanthus emblica. It is one of the Ayurveda medicinal recipes used to treat health …