The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome
conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Transcriptional memory is characterized by a primed cellular state, induced by an external
stimulus that results in an altered expression of primed genes upon re-exposure to the …

Conventional human embryonic stem cells are considered to be primed pluripotent but can
be induced to enter a naive state. However, the transcriptional features associated with …

Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC)
in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine …