Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

Aging is associated with a progressive decline in physiological capacities and an increased
risk of aging-associated disorders. An increasing body of experimental evidence shows that …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging.
Here, we asked whether the mitochondrial antiviral signaling protein (MAVS), which is …

The synovium, a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,
undergoes changes in aging that contribute to intense shoulder pain and other joint …

Aging is a complex and heterogeneous process, raising important questions about how
aging is differently impacted by underlying genetics and external factors. Recently …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent
among the elderly population. Urgent attention is required to prioritize preventive and …