Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Covalent modification of histones has an important role in regulating chromatin dynamics
and transcription. Whereas most covalent histone modifications are reversible, until recently …

Distal enhancers characterized by the H3K4me 1 mark play critical roles in developmental
and transcriptional programs. However, potential roles of specific distal regulatory elements …

Covalent modifications of histone tails have fundamental roles in chromatin structure and
function. One such modification, lysine methylation, has important functions in many …

To better understand the molecular mechanisms of depression and antidepressant action,
we administered chronic social defeat stress followed by chronic imipramine (a tricyclic …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA …

Histone lysine methylation is a central modification to mark functionally distinct chromatin
regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric …

Methylation of position-specific lysine residues in histone N termini is a central modification
for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist …