Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019 - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

[HTML][HTML] IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

Understanding the retinal basis of vision across species

T Baden, T Euler, P Berens - Nature Reviews Neuroscience, 2020 - nature.com
The vertebrate retina first evolved some 500 million years ago in ancestral marine
chordates. Since then, the eyes of different species have been tuned to best support their …

Exposure to microplastics decreases swimming competence in larval zebrafish (Danio rerio)

L Qiang, J Cheng - Ecotoxicology and environmental safety, 2019 - Elsevier
Microplastics have been frequently detected in both marine and freshwater ecosystems.
Their impact on aquatic organisms has raised much concern. This study investigated the …

[HTML][HTML] Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

C Chakraborty, AR Sharma, G Sharma… - Journal of …, 2016 - Springer
Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range
of industries, such as medicine, electronics and chemistry. In the current era, the commercial …

Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms

JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process

P Herbomel, B Thisse, C Thisse - Developmental biology, 2001 - Elsevier
The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly
understood. In the zebrafish embryo, we recently described a specific lineage of early …

[PDF][PDF] Zebrafish differentially process color across visual space to match natural scenes

MJY Zimmermann, NE Nevala, T Yoshimatsu, D Osorio… - Current Biology, 2018 - cell.com
Animal eyes have evolved to process behaviorally important visual information, but how
retinas deal with statistical asymmetries in visual space remains poorly understood. Using …

Modulation of locomotor activity in larval zebrafish during light adaptation

HA Burgess, M Granato - Journal of Experimental Biology, 2007 - journals.biologists.com
The neural basis of behavioral choice in vertebrates remains largely unknown. Zebrafish
larvae have a defined locomotor repertoire as well as a simple nervous system and are …

Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol

RC MacPhail, J Brooks, DL Hunter, B Padnos, TD Irons… - Neurotoxicology, 2009 - Elsevier
The increasing use of zebrafish (Danio rerio) in developmental research highlights the need
for a detailed understanding of their behavior. We studied the locomotion of individual …