Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

Hematopoietic stem and progenitor cells (HSPCs) are a heterogeneous group of cells with
expansion, differentiation, and repopulation capacities. How HSPCs orchestrate the …

Viruses have evolved various mechanisms to evade host immunity and ensure efficient viral
replication and persistence. Several DNA tumor viruses modulate host DNA …

Two major functions of the epigenome are to regulate gene expression and to suppress
transposons. It is unclear how these functions are balanced during physiological challenges …

We hypothesized that the highly controlled pattern of gene expression that is essential for
liver regeneration is encoded by an epigenetic code set in quiescent hepatocytes. Here we …

The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and
lifestyle factors; however, environmental toxicants are a frequently overlooked factor that can …