Air pollution exposure is estimated to contribute to approximately seven million early deaths
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Single-cell multiomics technologies typically measure multiple types of molecule from the
same individual cell, enabling more profound biological insight than can be inferred by …

Nowadays acute myocardial infarction (AMI) is a serious cardiovascular disease threatening
the human life and health worldwide. The most effective treatment is to quickly restore …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …

Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …

Abstract Ischemic/reperfusion (I/R) injury causes a series of serious clinical problems
associated with high morbidity and mortality in various disorders, such as acute kidney injury …

Widespread genome hypo-methylation and promoter hyper-methylation of epithelium-
specific genes are hallmarks of stable epithelial-to-mesenchymal transition (EMT), which in …

Epigenetic studies of both intragenerational and transgenerational epigenetic phenotypic
modifications have proliferated in the last few decades. However, the strong reductionist …