Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest
cells and showing heterogeneous biological, morphological, genetic and clinical …

Cancer is being reinterpreted in the light of recent discoveries related to the histone code
and the dynamic nature of epigenetic regulation and control of gene programs during …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

Recent studies suggest that endocrine disrupting chemicals (EDCs) may form a risk factor
for obesity by altering energy metabolism through epigenetic gene regulation. The goal of …

The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid
progression despite intensive multimodal therapy. This diversity is not fully explained by …

Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is
relevant to establish resistance to therapeutic approaches. The use of compounds direct …

The contribution of early virus-induced epigenetic changes to human papillomavirus (HPV)-
associated carcinogenesis is poorly understood. Using genome-wide methylation array …

Neuroblastoma (NB) is a neoplasm of the sympathetic nervous system, and is the most
common solid tumor of infancy. NBs are very heterogeneous, with a clinical course ranging …

Prolonged seizures (status epilepticus) produce pathophysiological changes in the
hippocampus that are associated with large-scale, wide-ranging changes in gene …

Background Accurate outcome prediction in neuroblastoma, which is necessary to enable
the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma …