Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

It is likely that most vertebrate genes are associated with 'HTF islands'—DNA sequences in
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …

The occurrence of reactive oxygen species, known as pro-oxidants, is an attribute of normal
aerobic life. The steady-state formation of pro-oxidants is balanced by a similar rate of their …

Unique DNA sequences can be determined directly from mouse genomic DNA. A
denaturing gel separates by size mixtures of unlabeled DNA fragments from complete …

Contemporary views on the structure and function of chromatin are presented and the
history of the development of these ideas as well as the nature of the nucleic acid and …

Up to 36% of Neurospora crassa transformants showing an albino phenotype were
recovered by transforming a wild‐type strain with different portions of the carotenogenic …

Active DNA demethylation is involved in many vital developmental and physiological
processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis …

Evidence from many sources shows that the control of gene expression in higher organisms
is related to the methylation of cytosine in DNA, and that the pattern of methylation is …

In the first half of the twentieth century, developmental biology and genetics were separate
disciplines. The word epigenetics was coined by Waddington to link the two fields …

One monomeric and three oligomeric potato spindle tuber viroid (PSTVd) cDNA units were
introduced into the tobacco genome via the Agrobacterium-mediated leaf-disc …