Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies

S Xu, I Ilyas, PJ Little, H Li, D Kamato, X Zheng… - Pharmacological …, 2021 - ASPET
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Mechanisms of oxidative stress in metabolic syndrome

SK Masenga, LS Kabwe, M Chakulya… - International journal of …, 2023 - mdpi.com
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches

DJ Medina-Leyte, O Zepeda-García… - International journal of …, 2021 - mdpi.com
Coronary artery disease (CAD) and its complications are the leading cause of death
worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the …

Oxidative stress in cardiovascular diseases

E Dubois-Deruy, V Peugnet, A Turkieh, F Pinet - Antioxidants, 2020 - mdpi.com
Reactive oxygen species (ROS) are subcellular messengers in signal transductions
pathways with both beneficial and deleterious roles. ROS are generated as a by-product of …

Oxidative stress status in COVID-19 patients hospitalized in intensive care unit for severe pneumonia. A pilot study

J Pincemail, E Cavalier, C Charlier, JP Cheramy–Bien… - Antioxidants, 2021 - mdpi.com
Background: A key role of oxidative stress has been highlighted in the pathogenesis of
COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 …

Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease

M Marizzoni, A Cattaneo, P Mirabelli… - Journal of …, 2020 - content.iospress.com
Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …

The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction

Y An, B Xu, S Wan, X Ma, Y Long, Y Xu… - Cardiovascular …, 2023 - Springer
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …

COVID-19 causes ferroptosis and oxidative stress in human endothelial cells

SS Jankauskas, U Kansakar, C Sardu, F Varzideh… - Antioxidants, 2023 - mdpi.com
Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the
pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought to …