DNA Methylation Biomarkers for Young Children with Idiopathic Autism Spectrum Disorder: A Systematic Review

A Stoccoro, E Conti, E Scaffei, S Calderoni… - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying
pathological mechanisms of which are not yet completely understood. Although several …

Interaction of the pre-and postnatal environment in the maternal immune activation model

A Gundacker, L Cuenca Rico, P Stoehrmann… - Discover mental …, 2023 - Springer
Adverse influences during pregnancy are associated with a range of unfavorable outcomes
for the developing offspring. Maternal psychosocial stress, exposure to infections and …

Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD+ production, and AhR activation in autism spectrum disorder

JM Launay, R Delorme, C Pagan, J Callebert… - Translational …, 2023 - nature.com
Hyperserotonemia is the most replicated biochemical anomaly associated with autism
spectrum disorder (ASD) and has been reported in 35–46% of individuals with ASD …

APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory

SA Harker, L Al-Hassan, MJ Huentelman… - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence
suggests that autistic adults are more likely to develop Alzheimer's disease (Alz) and other …

Dysregulation of immune and metabolism pathways in maternal immune activation induces an increased risk of autism spectrum disorders

H Yin, Z Wang, J Liu, Y Li, L Liu, P Huang, W Wang… - Life Sciences, 2023 - Elsevier
Aims Maternal immune activation (MIA) via infection during pregnancy is known to be an
environmental risk factor for neurodevelopmental disorders and the development of autism …

Cancer drug repurposing in autism spectrum disorder

G Pedini, CL Chen, T Achsel, C Bagni - Trends in Pharmacological …, 2023 - cell.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with uncertain
origins. Understanding of the mechanisms underlying ASD remains limited, and treatments …

Hippocampal and peripheral blood DNA methylation signatures correlate at the gene and pathway level in a mouse model of autism

CD Alberca, LA Papale, A Madrid… - Human Molecular …, 2023 - academic.oup.com
Autism spectrum disorders (ASD) are polygenic multifactorial disorders influenced by
environmental factors. ASD-related differential DNA methylation has been found in human …

Observational methods for human studies of transgenerational effects

R Richards-Steed, N Wan, A Bakian, RM Medina… - Epigenetics, 2024 - Taylor & Francis
There are substantial challenges in studying human transgenerational epigenetic outcomes
resulting from environmental conditions. The task requires specialized methods and tools …

[HTML][HTML] Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis

RE Frye, N Rincon, PJ McCarty, D Brister… - Neurobiology of …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children
and is associated with physiological abnormalities, most notably mitochondrial dysfunction …

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

AB Csoka, N El Kouhen, S Bennani, B Getachew… - Biomolecules, 2024 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe
deficits in social communication and interaction, repetitive movements, abnormal focusing …