Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

Abstract Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food
commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has …

Implantation of the embryo into the endometrium is a critical step in the establishment of
pregnancy and the failure of embryos to implant is a major limiting factor in the success of …

Malignant peripheral nerve sheath tumors (MPNSTs) are heterogeneous, highly aggressive
tumors with no widely effective treatment other than surgery. Genomic architecture of …

Background Some sarcomas respond to immune checkpoint inhibition, but predictive
biomarkers are unknown. We analyzed tumor DNA methylation profiles in relation to …

Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with
high metastatic risk and relatively few efficient systemic therapies. In the quest for new …

Background Recently, recurrent point mutations in the telomerase reverse transcriptase
(TERT) promoter region have been found in many human cancers, leading to a new …

The invasion cascade exhibited by placental trophoblasts and cancerous cells bears many
similarities, and it is attributed to extracellular matrix degradation mediated by matrix …