Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung
cancer and the third leading cause of cancer-related mortality after lung and colon cancer …

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23. 3 is a negative
regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor …

Clinical experience of histone deacetylase inhibitors (HDACIs) in patients with solid tumors
has been disappointing; however, the molecular mechanism of treatment failure is not …

Prostate cancer has become a real public health issue in industrialized countries, mainly
due to patients' relapse by castration-refractory disease after androgen ablation. Castration …

Abstract Purpose of Review An important number of newly identified molecular alterations in
prostate cancer affect gene encoding master regulators of chromatin biology epigenetic …

It is believed that epigenetic modification plays roles in cancer initiation and progression.
Both microRNA and DNA methyltransferase are epigenetic regulation factors. It was found …

Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …

Silibinin, extracted from milk thistle (Silybum marianum L.), has exhibited considerable
preclinical activity against prostate carcinoma. Its antitumor and chemopreventive activities …