In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Background We recently showed that enzymes of the TET family convert 5-mC to 5-
hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

Background Post-translational modifications of histones play important roles in maintaining
normal transcription patterns by directly or indirectly affecting the structural properties of the …

Current DNA methylation assays are limited in the flexibility and efficiency of characterizing
a large number of genomic targets. We report a method to specifically capture an arbitrary …

Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …

The biological significance of interactions of nuclear proteins with DNA in the context of
gene expression, cell differentiation, or disease has immensely been enhanced by the …

Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …