Insomnia disorder comprises symptoms during night and day that strongly affect quality of
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …

Sleep is a complex physiological process and is a critical determinant of physical and
mental health. In the past decades, significant progress has been made in understanding …

Progress in the field of insomnia since 2017 necessitated this update of the European
Insomnia Guideline. Recommendations for the diagnostic procedure for insomnia and its …

While sleep serves important regulatory functions for mental health, sleep disturbances, in
particular insomnia, may favour a state of allostatic overload impairing brain neuroplasticity …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Insomnia disorder (ID) has become the second-most common mental disorder. Despite
burgeoning evidence for increased high-frequency electroencephalography (EEG) activity …

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces
sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity …

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …

Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC)
norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep …

In our daily life, we are exposed to uncontrollable and stressful events that disrupt our sleep.
However, the underlying neural mechanisms deteriorating the quality of non-rapid eye …