Convection-enhanced delivery (CED) is a promising technique that generates a pressure
gradient at the tip of an infusion catheter to deliver therapeutics directly through the …

This article is focused on reviewing the current state-of-the-art of optical fibre pressure
sensors for medical applications. Optical fibres have inherent advantages due to their small …

Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug
delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) …

Alzheimer's disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy,
neuronal death and progressive loss of cognitive functions. It is commonly assumed that …

Focused ultrasound combined with intravenously injected microbubbles (FUS) is known to
non-invasively, locally, and transiently increase the permeability of the blood-brain barrier …

We report on the successful delivery of the Cre recombinase enzyme in the neural cells of
mice in vivo by simple coinjection with peptides derived from HIV-TAT. Cre delivery activates …

Biological soft tissues manipulation, including conventional (mechanical) and
nonconventional (laser, waterjet and ultrasonic) processes, is critically required in most …

Background Convection enhanced delivery (CED) infuses drugs directly into brain tissue.
Needle insertion is required and results in tissue damage which can promote flowback …

Gene delivery to the central nervous system (CNS) has potential as a means for treating
numerous debilitating neurological diseases. Nonviral gene vector platforms are tailorable …

Glioblastoma multiforme (GBM) is the most aggressive form of brain tumour and treatment is
very challenging. Despite the recent advances in drug delivery systems, various approaches …