High throughput fabrication of robust solid microneedles
Needles are a key, and very common, component of modern medicine, used primarily for
drug delivery and blood withdrawals. There are, however, many drawbacks to their use …
drug delivery and blood withdrawals. There are, however, many drawbacks to their use …
A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain
Background To understand the role of microglia in brain function and development, methods
have emerged to deplete microglia throughout the brain. Liposome-encapsulated …
have emerged to deplete microglia throughout the brain. Liposome-encapsulated …
Novel Approaches to Bypassing the Blood-Brain Barrier for Drug Delivery to Brain Tumors
Brain tumors are a group of heterogeneous diseases arising from abnormally proliferating
cells that can negatively impact the eloquent function of this organ. Drug therapies have …
cells that can negatively impact the eloquent function of this organ. Drug therapies have …
[HTML][HTML] Parametric analysis of drug distribution during infusions into the brain using an axisymmetric model with backflow
Convection-enhanced delivery as a means to deliver therapeutic drugs directly to the brain
has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in …
has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in …
Quantitative Assessment of the Mechanical Properties of the Neural Interface
A Sridharan, J Muthuswamy - Handbook of Neuroengineering, 2023 - Springer
Recent studies provide compelling evidence that besides the implant material, a
combination of implant size and implant stiffness determines the long-term integrity and …
combination of implant size and implant stiffness determines the long-term integrity and …
Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats
B Zhao, C Zou, P Zhou - Behavioural brain research, 2016 - Elsevier
In order to study the protective effects on motor and cognitive function by inhibiting IL-1β as
delayed as 24 h after global ischemia, we designed behavioral testing protocol and …
delayed as 24 h after global ischemia, we designed behavioral testing protocol and …
Design and Characterization of Pressure Monitoring and Insertion system for Intraparenchymal Convection Enhanced Delivery
J Michiels, F Vitale - … Conference of the IEEE Engineering in …, 2023 - ieeexplore.ieee.org
Neurological disorders are a significant societal and economic burden. Common
pharmacological therapies often can only manage symptoms and have limited efficacy …
pharmacological therapies often can only manage symptoms and have limited efficacy …
Tip design for safety of steerable needles for robot-controlled brain insertion
CA Lehocky, W Fellows-Mayle, JA Engh… - Robotic Surgery …, 2017 - Taylor & Francis
Background Current practice in neurosurgical needle insertion is limited by the straight
trajectories inherent in rigid probes. One technique allowing curvilinear trajectories involves …
trajectories inherent in rigid probes. One technique allowing curvilinear trajectories involves …
Tumor ablation due to inhomogeneous anisotropic diffusion in generic three-dimensional topologies
In recent decades computer-aided technologies have become prevalent in medicine,
however, cancer drugs are often only tested on in vitro cell lines from biopsies. We derive a …
however, cancer drugs are often only tested on in vitro cell lines from biopsies. We derive a …
Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhanced Delivery
K Negron, N Khalasawi, JS Suk - Nanotherapy for Brain Tumor Drug …, 2021 - Springer
Convection enhanced delivery (CED) is an attractive method to bypass the blood-brain
barrier for therapeutic delivery to the brain as well as to facilitate widespread therapeutic …
barrier for therapeutic delivery to the brain as well as to facilitate widespread therapeutic …