[HTML][HTML] Reelin functions, mechanisms of action and signaling pathways during brain development and maturation

Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

[HTML][HTML] Shaping synapses by the neural extracellular matrix

M Ferrer-Ferrer, A Dityatev - Frontiers in neuroanatomy, 2018 - frontiersin.org
Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

[HTML][HTML] GWAS on family history of Alzheimer's disease

RE Marioni, SE Harris, Q Zhang, AF McRae… - Translational …, 2018 - nature.com
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …

[HTML][HTML] New insights into reelin-mediated signaling pathways

GH Lee, G D'Arcangelo - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …

[HTML][HTML] Fyn tyrosine kinase as harmonizing factor in neuronal functions and dysfunctions

C Matrone, F Petrillo, R Nasso, G Ferretti - International journal of …, 2020 - mdpi.com
Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family
kinases (SFKs) involved in multiple transduction pathways in the central nervous system …

[HTML][HTML] Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

[HTML][HTML] The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor

P Dlugosz, J Nimpf - International journal of molecular sciences, 2018 - mdpi.com
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …

[HTML][HTML] ADAMTS expression and function in central nervous system injury and disorders

PE Gottschall, MD Howell - Matrix Biology, 2015 - Elsevier
The components of the adult extracellular matrix in the central nervous system form a lattice-
like structure that is deposited as perineuronal nets, around axon initial segments and as …

[HTML][HTML] De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism

M Riva, S Ferreira, K Hayashi, Y Saillour… - The Journal of Clinical …, 2024 - jci.org
Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In
humans, recessive RELN variants cause cortical and cerebellar malformations, while …

[HTML][HTML] Reelin signaling in neurodevelopmental disorders and neurodegenerative diseases

A Joly-Amado, N Kulkarni, KR Nash - Brain Sciences, 2023 - mdpi.com
Reelin is an extracellular matrix glycoprotein involved in neuronal migration during
embryonic brain development and synaptic plasticity in the adult brain. The role of Reelin in …