It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Membrane proteins remain challenging targets for structural biologists, despite recent
technical developments regarding sample preparation and structure determination. We …

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is
expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and …

Autosomal dominant polycystic kidney disease is characterized by the loss-of-function of a
signaling complex involving polycystin-1 and polycystin-2 (TRPP2, an ion channel of the …

TRPV4 (Transient Receptor Potential Vanilloid 4) channels are activated by a wide range of
stimuli, including hypotonic stress, non-noxious heat and mechanical stress and some small …

Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney
disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that …

Mutations in polycystin-1 and transient receptor potential polycystin 2 (TRPP2) account for
almost all clinically identified cases of autosomal dominant polycystic kidney disease …

Structural studies on TRP channels, while limited, are poised for a quickened pace and
rapid expansion. As of yet, no high-resolution structure of a full length TRP channel exists …

Dysregulation of Ca2+ signaling and homeostasis has been linked to the development of
ADPKD through aberrant functioning of the polycystins. In this study, we investigated the role …

The C-terminal cytoplasmic tail of polycystin-2 (PC2/TRPP2), a Ca2+-permeable channel, is
frequently mutated or truncated in autosomal dominant polycystic kidney disease. We have …