Heat activation mechanism of TRPV1: New insights from molecular dynamics simulation
W Zheng, H Wen - Temperature, 2019 - Taylor & Francis
As a member of the transient receptor potential (TRP) channels superfamily, the TRPV1
channel undergoes a closed-to-open gating transition in response to various physical and …
channel undergoes a closed-to-open gating transition in response to various physical and …
[图书][B] Calcium binding proteins
E Permyakov, RH Kretsinger - 2011 - books.google.com
Calcium Binding Proteins explains the unique and highly diverse functions of calcium in
biology, which are realized by calcium binding proteins. The structures and physical …
biology, which are realized by calcium binding proteins. The structures and physical …
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating
AS Ćelić, ET Petri, J Benbow, ME Hodsdon… - Journal of Biological …, 2012 - ASBMB
Polycystin-2 (PC2) is a Ca 2+-permeable transient receptor potential channel activated and
regulated by changes in cytoplasmic Ca 2+. PC2 mutations are responsible for∼ 15% of …
regulated by changes in cytoplasmic Ca 2+. PC2 mutations are responsible for∼ 15% of …
Decrypting the heat activation mechanism of TRPV1 channel by molecular dynamics simulation
H Wen, W Zheng - Biophysical journal, 2018 - cell.com
As a prototype cellular sensor, the TRPV1 cation channel undergoes a closed-to-open
gating transition in response to various physical and chemical stimuli including noxious …
gating transition in response to various physical and chemical stimuli including noxious …
Ligand-induced conformational changes enable intersubunit communications in D-dopachrome tautomerase
Abstract D-Dopachrome tautomerase (D-DT; or MIF-2) is a multifunctional protein with
immunomodulatory properties and a documented pathogenic role in inflammation and …
immunomodulatory properties and a documented pathogenic role in inflammation and …
Ion channels in renal disease
IY Kuo, BE Ehrlich - Chemical reviews, 2012 - ACS Publications
The cells of the kidney contain many specialized ion channels and transporters, which act in
concert to regulate volume and ionic concentration by absorption or secretion of ions into the …
concert to regulate volume and ionic concentration by absorption or secretion of ions into the …
A high‐resolution structure of the EF‐hand domain of human polycystin‐2
MD Allen, S Qamar, MK Vadivelu, RN Sandford… - Protein …, 2014 - Wiley Online Library
Autosomal dominant polycystic kidney disease (ADPKD) affects over 1: 1000 of the
worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 …
worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 …
Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2
KL Molland, A Narayanan, JW Burgner… - Biochemical …, 2010 - portlandpress.com
Polycystin 2-type cation channels PKD2 and PKD2L1 interact with polycystin 1-type proteins
PKD1 and PKD1L3 respectively, to form receptor–cation-channel complexes. The PKD2L1 …
PKD1 and PKD1L3 respectively, to form receptor–cation-channel complexes. The PKD2L1 …
X-ray crystallography of TRP channels
Transient receptor potential (TRP) ion channels are molecular sensors of a large variety of
stimuli including temperature, mechanical stress, voltage, small molecules including …
stimuli including temperature, mechanical stress, voltage, small molecules including …
An explicit formulation approach for the analysis of calcium binding to EF-hand proteins using isothermal titration calorimetry
We present an improved and extended version of a recently proposed mathematical
approach for modeling isotherms of ligand-to-macromolecule binding from isothermal …
approach for modeling isotherms of ligand-to-macromolecule binding from isothermal …