Aims Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is
effective, but also associated with cardiac toxicity. Previous studies have reported on the …

Objective: To describe mean arterial blood pressure (MABP), responsiveness to dopamine,
and relationship to brain injury in infants with moderate/severe hypoxic-ischemic …

The present study determined whether treatment during childhood with topiramate (TPM), a
new generation antiepileptic drug, results in altered aortic reactivity in adult male and female …

ABSTRACT Introduction: Antiepileptic drugs (AEDs) are administered orally for chronic use.
Parenteral formulations might be necessary when the oral route is not feasible (eg an …

Abstract Introduction: The Antiepileptic medications are frequently categorized into divisions
such as 'first-generation'(ie, carbamazepine, phenobarbital, phenytoin, primidone, and …

Phenobarbital is a first-line treatment of various seizure types in newborns. Dosage
individualization maximizing the proportion of patients with drug levels in therapeutic range …

Background: Hypoxic ischemic encephalopathy (HIE) is brain injury caused by different
reasons and the most common diagnosed is neonatal HIE. Most of the existing treatments …

Approximately 65% of children with newly diagnosed epilepsy achieve sustained control of
their epileptic seizures with the antiepileptic drug (AED) initially prescribed, and 15-20 …

Approximately 1% of the world population suffers from epilepsy, a neurological disorder
characterized by repeated seizures. In vitro models that capture the complexity of the human …

Method We will perform a systematic review including randomised controlled studies
(RCTs), cohort studies, case-controlled studies and case series studies which evaluated the …