DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Mammalian sperm and oocytes have different epigenetic landscapes and are organized in
different fashions. After fertilization, the initially distinct parental epigenomes become largely …

Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

Genome-wide association studies of complex physiological traits and diseases consistently
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …

The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …