Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by
intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually …

The coronavirus disease 2019 (COVID-19) pandemic has claimed several thousand lives
since the first case was described in Wuhan, China, in December 2019. 1 This has mainly …

ABSTRACT Introduction SARS-CoV-2, the causative agent of COVID-19, attacks the
immune system causing an exaggerated and uncontrolled release of pro-inflammatory …

Coagulation and innate immunity are linked evolutionary processes that orchestrate the host
defence against invading pathogens and injury. The complement system is integral to innate …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of
potentially life-threatening autoimmune diseases. The main histological feature in the …

Aims We recently reported five cases of vaccine-induced immune thrombotic
thrombocytopenia (VITT) 7–10 days after receiving the first dose of the ChAdOx1 nCoV-19 …