[HTML][HTML] Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
The alternative role of DNA methylation in splicing regulation
Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …
[HTML][HTML] DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
[HTML][HTML] Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Interpreting noncoding genetic variation in complex traits and human disease
Association studies provide genome-wide information about the genetic basis of complex
disease, but medical research has focused primarily on protein-coding variants, owing to the …
disease, but medical research has focused primarily on protein-coding variants, owing to the …
[HTML][HTML] Cigarette smoking and DNA methylation
KWK Lee, Z Pausova - Frontiers in genetics, 2013 - frontiersin.org
DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
Comparative studies of gene expression and the evolution of gene regulation
The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease
CL Relton, G Davey Smith - International journal of …, 2012 - academic.oup.com
The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …
approaches to strengthen causal inference when considering the role of epigenetic …
Removing technical variability in RNA-seq data using conditional quantile normalization
The ability to measure gene expression on a genome-wide scale is one of the most
promising accomplishments in molecular biology. Microarrays, the technology that first …
promising accomplishments in molecular biology. Microarrays, the technology that first …
Prenatal maternal stress predicts methylation of genes regulating the hypothalamic–pituitary–adrenocortical system in mothers and newborns in the Democratic …
Exposure to stress early in life permanently shapes activity of the hypothalamic–pituitary–
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …