The expression of the large amino acid transporter, LAT1, was investigated in brain of adult
Long-Evans rats. The LAT1 transcript was readily detected in brain microvessels and …

Background Autism spectrum disorder (ASD) is a common neurodevelopmental disorder
whose molecular mechanisms are largely unknown. Several studies have shown an …

Heteromeric amino acid transporters (HATs) are composed of a heavy (SLC3 family) and a
light (SLC7 family) subunit. Mutations in system b0,+(rBAT-b0,+ AT) and in system y+ L …

The molecular identification of almost all physiologically characterized amino acid
transporters in recent years has facilitated the functional analysis of this important class of …

We identified an amino acid transporter that is associated with the cystinuria-related type II
membrane glycoprotein, rBAT (related to b 0,+ amino acid transporter). The transporter …

OBJECTIVE: To study the expression and function of L-type amino acid transporter 1 (LAT1),
a major catalytic subunit of system L that is responsible for the transport of large neutral …

Thyroid hormones (TH) are important for the development of the human fetus and placenta
from very early gestation. The transplacental passage of TH from mother to fetus and the …

In the tumor microenvironment, arginine is metabolized by arginase-expressing myeloid
cells. This arginine depletion profoundly inhibits T cell functions and is crucially involved in …

LAT1 and 4F2hc form a heterodimeric membrane protein complex, which functions as one of
the best characterized amino acid transporters. Since LAT1–4F2hc is required for the …

Purpose: L-Type amino acid transporter 1 (LAT1) is highly expressed in cancer cells to
support their continuous growth and proliferation. We have examined the effect of 2 …