Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …

Now a day's intranasal (in) drug delivery is emerging as a reliable method to bypass the
blood–brain barrier (BBB) and deliver a wide range of therapeutic agents including both …

Benzodiazepines (BZDs) remain important agents in the management of epilepsy. They are
drugs of first choice for status epilepticus and seizures associated with post‐anoxic insult …

In order to assess the significance of drug levels measured in clinical and forensic toxicology
as well as for Therapeutic Drug Monitoring (TDM) it is essential that good collections of data …

Background Rectal diazepam and buccal midazolam are used for emergency treatment of
acute febrile and afebrile (epileptic) seizures in children. We aimed to compare the safety …

Background Episodes of childhood convulsive status epilepticus (CSE) commonly start in
the community. Treatment of CSE aims to minimise the length of seizures, treat the causes …

Background: Rapid treatment of status epilepticus (SE) is associated with better outcomes.
Diazepam and midazolam are commonly used, but the optimal agent and administration …

The aim of this investigation was to prepare clonazepam microemulsions (CME) for rapid
drug delivery to the brain to treat acute status epileptic patients and to characterize and …