▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

The expression of the insulin-like growth factor 2 (Igf2) and H19 genes is imprinted.
Although these neighbouring genes share an enhancer, H19 is expressed only from the …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …

Epigenetic alterations may mechanistically explain the developmental origins of adult
disease, namely the hypothesis that many complex adult chronic diseases originate as a …

The bic locus is a common retroviral integration site in avian leukosis virus (ALV)-induced B-
cell lymphomas originally identified by infection of chickens with ALVs of two different …

Loss of imprinting at IGF2, generally through an H19-independent mechanism, is associated
with a large percentage of patients with the overgrowth and cancer predisposition condition …

Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

Imprinting is defined as the parental allele‐specific expression of a very limited set of genes
(about 50–80). This regulation depends upon an epigenetic marking of parental alleles …