The flexibility of the epigenome has generated an enticing argument to explore its reversion
through pharmacological treatments as a strategy to ameliorate disease phenotypes. All …

Simple Summary Research on plant epigenetics aims to understand how endogenous,
biotic, and abiotic factors regulate plant development and growth independent of changes in …

Background Modulating the epigenome has long been considered a potential opportunity
for therapeutic intervention in numerous disease areas with several approved therapies …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Hepatocellular carcinoma (HCC), the most common liver malignancy with a poor prognosis
and increasing incidence, remains a serious health problem worldwide. Immunotherapy has …

Mitochondria are organelles responsible for several functions involved in cellular balance,
including energy generation and apoptosis. For decades now, it has been well-known that …

Histone H3 lysine 27 methylation catalyzed by polycomb repressive complex 2 (PRC2) is
conserved from fungi to humans and represses gene transcription. However, the mechanism …

Mesenchymal stem cells (MSCs) are adult stem cells harboring self-renewal and
multilineage differentiation potential that are capable of differentiating into osteoblasts …

Epitranscriptomics is an exciting emerging area that studies biochemical modifications of
RNA. The field has been opened up by the technical efforts of the last decade to …

ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of
cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of …