Arginine methylation is an important mechanism of epigenetic regulation. Some Fe (II) and 2‐
oxoglutarate dependent Jumonji‐C (JmjC) Nϵ‐methyl lysine histone demethylases also …

The Nε-methyl lysine status of histones is important in the regulation of eukaryotic
transcription. The Fe (II) and 2-oxoglutarate (2OG)-dependent JmjC domain enzymes are …

Abstract Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is
attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a …

The characteristics of innate immunity have recently been investigated in depth in several
research articles, and original findings suggest that innate immunity also has a memory …

Schistosomiasis endangers the lives of greater than 200 million people every year and is
predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development …

The development of vaccines is one of the greatest medical interventions in the history of
global infectious diseases and has contributed to the annual saving of at least 2 to 3 million …

Background Praziquantel represents the frontline chemotherapy used to treat
schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro …

The antitumour effects of OTX015, a first-in-class BET inhibitor (BETi), were investigated as a
single agent or in combination with ionizing radiation (IR) in preclinical in vitro models of …

The pathogenesis of inflammatory bowel diseases (IBD) involves genetic predisposition,
environmental factors, and a broadly dysregulated intestinal immune response to the …

Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of
hematological malignancies. Here, we report the design, synthesis, and profiling of new …