Abstract Fe (II)/α-ketoglutarate-dependent lysine demethylases (KDMs) are attractive drug
targets for several diseases including cancer. In this study, we designed and screened ortho …

In Chap. 1, we have learned that the modern pharmacological therapy of human disease
and new drug discovery are based primarily on four major strategies/modality: the STD …

组蛋白甲基转移酶SUV4-20H 为哺乳动物组蛋白H4 第20 位赖氨酸(H4K20)
的特异性甲基转移酶, 在人体组织中广泛表达. SUV4-20H 蛋白本身及其介导的H4K20 …

Chromatin is an organized complex of DNA, histone proteins, and RNA. Chromatin
modifications include DNA methylation, RNA methylation, and histone acetylation and …

Epigenetics is defined as heritable alterations in gene expression that are not caused by
changes in DNA sequence. Such normal alterations are vital for appropriate differentiation …

■ Abstract Mitochondria are metabolic organelles responsible for cellular functions such as
development, division, energy metabolism by oxidative phosphorylation (OXPHOS) …

Die Zusammenhänge zwischen der Aktivität Epigenetik-assoziierter Enzyme und
Krankheitsgeschehen neoplastischer Art konnten nicht nur experimentell bestätigt, sondern …

The COMPASS/MLL family of H3K4 methyltransferases is highly conserved throughout the
eukaryotic kingdom [1]. MLL4 (KMT2D) is a main H3K4 methyltransferase responsible for …

DNA methyltransferase 3A (DNMT3A) has been regarded as a potential epigenetic target for
the development of cancer therapeutics. A number of DNMT3A inhibitors have been …

Targeting of proteins in the histone modification machinery has emerged as a promising
new direction to fight disease. The search for compounds that inhibit proteins that readout …