The COMPASS/MLL family of H3K4 methyltransferases is highly conserved throughout the
eukaryotic kingdom [1]. MLL4 (KMT2D) is a main H3K4 methyltransferase responsible for …

Targeting of proteins in the histone modification machinery has emerged as a promising
new direction to fight disease. The search for compounds that inhibit proteins that readout …

Several studies have suggested a key role of DNA sequence variants in modulating the
response to treatment in patients with bipolar disorder. However, as a multifactorial disorder …

•(2-HG, 2-hydroxyglutarate), 2-υδροξυ-γλουταρικό•(3′-UTR, three prime untranslated
region), 3′-μη μεταφράσιμη περιοχή•(5′-UTR, Five prime untranslated region), 5′-μη …

DNA methyltransferase 3A (DNMT3A) has been regarded as a potential epigenetic target for
the development of cancer therapeutics. A number of DNMT3A inhibitors have been …

[0001] The present application claims the benefit of EP patent application serial number
19183317.7, filed on 21 Oct. 2019, the content of which is incorporated herein by reference …

Probiotics are known as “live microorganisms” and have been proven to have a health effect
on hosts at the proper dose. Recently, a kind of probiotic mixture including eight live …