Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck

J Zhuang, H Zhu, Z Cheng, X Hu, X Yu, J Li, H Liu… - Scientific Reports, 2023 - nature.com
The gene expression profile of abdominal aortic aneurysm (AAA) neck is not fully
understood. The etiology of AAA is considered to be related to atherosclerosis and the …

Expression pattern and clinical value of key m6A RNA modification regulators in abdominal aortic aneurysm

T Li, T Wang, J Jing, L Sun - Journal of inflammation research, 2021 - Taylor & Francis
Background Aberrant expression of N6-methyladenosine (m6A) RNA modification
regulators plays a critical role in a variety of human diseases. However, their implication in …

Importance of NLRP3 inflammasome in abdominal aortic aneurysms

J Shi, J Guo, Z Li, B Xu, M Miyata - Journal of atherosclerosis and …, 2021 - jstage.jst.go.jp
Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease,
which particularly affects older people. Nucleotide-binding oligomerization domain-like …

Dapagliflozin ameliorates the formation and progression of experimental abdominal aortic aneurysms by reducing aortic inflammation in mice

H Liu, P Wei, W Fu, C Xia, Y Li, K Tian… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Dapagliflozin, a sodium glucose transporter protein‐2 (SGLT‐2) inhibitor,
reduces the risk for cardiovascular diseases. However, the influence of dapagliflozin on …

Aneurysm and artery dissection after oral VEGFR-TKI use in adults with cancer

S Kang, B Yeon, MS Kim, M Yoo, B Kim… - JAMA Network …, 2023 - jamanetwork.com
Importance The association of tyrosine kinase inhibitors targeting vascular endothelial
growth factor receptors (VEGFR-TKIs) with aneurysm and artery dissection (AAD) has been …

CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4

J Yue, T Zhu, J Yang, Y Si, X Xu, Y Fang, W Fu - Life sciences, 2020 - Elsevier
Heading aims Abdominal aortic aneurysm (AAA) is featured by the growth impediment and
apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are …

C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms

Y Fu, H Liu, K Li, P Wei, N Alam, J Deng, M Li… - Frontiers in …, 2023 - frontiersin.org
Background C-reactive protein (CRP) levels are elevated in patients with abdominal aortic
aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA …

Relationships between perivascular adipose tissue and abdominal aortic aneurysms

T Ye, G Zhang, H Liu, J Shi, H Qiu, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are typically asymptomatic, and there is a high mortality
rate associated with aneurysm rupture. AAA pathogenesis involves extracellular matrix …