Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Epigenetics investigates heritable changes in gene expression that occur without changes
in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone …

Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …

Environmental toxicants can alter epigenetic regulatory features such as DNA methylation
and microRNA expression. As the sensitivity of epigenomic regulatory features may be …

DNA methylation is an important regulator of genetic information in species ranging from
bacteria to humans. DNA methylation appears to be critical for mammalian development …

CpG island hypermethylation is a mechanism of gene silencing that can be usurped by
neoplastic cells to inactivate undesirable genes. In the colon, hypermethylation often starts …

DNA methylation of promoter-associated CpG islands may function as an alternate
mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

Hypermethylation in cancer often occurs in CpG islands that span the promoter regions of
tumor suppressor genes. However, it is not clear if hypermethylation is limited to single …