[HTML][HTML] Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …
expression, which is highly dynamic during development and specifically maintained in …
Principles of DNA methylation and their implications for biology and medicine
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …
providing instruction as to how and when to read the information and control transcription …
Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
[HTML][HTML] Epigenetics of aging and aging-associated diseases
D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
[HTML][HTML] Editing DNA methylation in the mammalian genome
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …
expression networks in many biological processes. However, investigation of the functions …
[HTML][HTML] Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene
Fragile X syndrome (FXS), the most common genetic form of intellectual disability in males,
is caused by silencing of the FMR1 gene associated with hypermethylation of the CGG …
is caused by silencing of the FMR1 gene associated with hypermethylation of the CGG …
[HTML][HTML] A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1
N Chen, G Zhao, X Yan, Z Lv, H Yin, S Zhang, W Song… - Genome biology, 2018 - Springer
Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …