[HTML][HTML] The roles of MAPKs in disease
MC Lawrence, A Jivan, C Shao, L Duan, D Goad… - Cell research, 2008 - nature.com
MAP kinases transduce signals that are involved in a multitude of cellular pathways and
functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate …
functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate …
[HTML][HTML] A TR (i) P to cell migration: New roles of TRP channels in mechanotransduction and cancer
J Canales, D Morales, C Blanco, J Rivas… - Frontiers in …, 2019 - frontiersin.org
Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from
the primary tumor to distant organs. At the molecular level, migration is the result of several …
the primary tumor to distant organs. At the molecular level, migration is the result of several …
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
S Shibazaki, Z Yu, S Nishio, X Tian… - Human molecular …, 2008 - academic.oup.com
Polycystic kidney disease (ADPKD) results from failure of the kidney to properly maintain
three-dimensional structure after loss of either polycystin-1 or-2. Mice with kidney selective …
three-dimensional structure after loss of either polycystin-1 or-2. Mice with kidney selective …
Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling
M Lal, X Song, JL Pluznick, V Di Giovanni… - Human molecular …, 2008 - academic.oup.com
Abstract Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of
autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage …
autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage …
The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation
SUMMARY Mutations in polycystin1 (PKD1) account for the majority of autosomal dominant
polycystic kidney disease (ADPKD). PKD1 mutations are also associated with vascular …
polycystic kidney disease (ADPKD). PKD1 mutations are also associated with vascular …
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
YH Choi, A Suzuki, S Hajarnis, Z Ma… - Proceedings of the …, 2011 - National Acad Sciences
Polycystic kidney disease (PKD) is a genetic disorder that is characterized by cyst formation
in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle …
in kidney tubules. PKD arises from abnormalities of the primary cilium, a sensory organelle …
Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease
Y Zhang, G Reif, DP Wallace - Cellular signalling, 2020 - Elsevier
In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1
Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose
dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has …
dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has …
Calcium signaling in polycystic kidney disease-cell death and survival
KM Márquez-Nogueras, V Vuchkovska, IY Kuo - Cell Calcium, 2023 - Elsevier
Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …
including hypertension and heart failure. The main genetic underpinning this disease are …
[HTML][HTML] Emerging evidence of a link between the polycystins and the mTOR pathways
A Boletta - Pathogenetics, 2009 - Springer
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized
by the formation of renal cysts. This disease can be caused by mutations in two genes …
by the formation of renal cysts. This disease can be caused by mutations in two genes …