Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant
challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Chemotherapy-induced cardiac damage remains a leading cause of death amongst cancer
survivors. Anthracycline-induced cardiotoxicity is mediated by severe mitochondrial injury …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Cyclophosphamide has drastically enhanced the expectancy and quality of life of cancer
patients. However, it is accompanied by diverse neurological complications which are …

Aims Microbial infection is the main factor that induces mastitis. Staphylococcus aureus (S.
aureus) is a major pathogen associated with mastitis. The purpose of this study was to …