This article provides an overview of MRI methods exploiting magnetic susceptibility
properties of blood to assess cerebral oxygen metabolism, including the tissue oxygen …

What defines the rate of energy use by the brain, as well as per neurons of different sizes in
different structures and animals, is one fundamental aspect of neuroscience for which much …

Purpose Renal metabolic rate of oxygen (rMRO2) is a potentially important biomarker of
kidney function. The key parameters for rMRO2 quantification include blood flow rate (BFR) …

Quantitative BOLD (qBOLD) MRI allows evaluation of oxidative metabolism of the brain
based purely on an endogenous contrast mechanism. The method quantifies deoxygenated …

Alzheimer's disease (AD) is the leading cause of cognitive impairment and dementia in
elderly individuals. According to the current biomarker framework for “unbiased descriptive …

The metabolic rate of oxygen (MRO2) is fundamental to tissue metabolism. Determination of
MRO2 demands knowledge of the arterio-venous difference in hemoglobin-bound oxygen …

Sleep, a state of reduced consciousness, affects brain oxygen metabolism and lowers
cerebral metabolic rate of oxygen (CMRO2). Previously, we quantified CMRO2 during sleep …

One promising approach for mapping CMRO2 is dual-calibrated functional MRI (dc-fMRI).
This method exploits the Fick Principle to combine estimates of CBF from ASL, and OEF …

Abstract Knowledge of input blood to the brain, which is represented as total cerebral blood
flow (tCBF), is important in evaluating brain health. Phase-contrast (PC) magnetic resonance …

Abstract Purpose of Review There is a contemporary push to map tissues and their disease
states quantitatively at single-cell and spatial resolution, but standard assays to do so, such …