DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration

JD Nguyen, J Llamas, T Shi… - Proceedings of the …, 2023 - National Acad Sciences
Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration

JD Nguyen, J Llamas, T Shi, JG Crump… - Proceedings of the …, 2023 - ui.adsabs.harvard.edu
Age-related hearing loss can significantly impact quality of life. One potential approach to
restore hearing is to regenerate mechanosensory hair cells responsible for detecting sound …

[HTML][HTML] DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration

JD Nguyen, J Llamas, T Shi, JG Crump… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Results Cochlear Progenitor Cells, Hair Cells, and Supporting Cells Have Distinct DNA
Methylation Signatures. We hypothesized that systemic heterochromatinization contributes …

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration.

JD Nguyen, J Llamas, T Shi, JG Crump… - Proceedings of the …, 2023 - europepmc.org
Results Cochlear Progenitor Cells, Hair Cells, and Supporting Cells Have Distinct DNA
Methylation Signatures. We hypothesized that systemic heterochromatinization contributes …

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration

JD Nguyen, J Llamas, T Shi… - Proceedings of the …, 2023 - pubmed.ncbi.nlm.nih.gov
Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration.

JD Nguyen, J Llamas, T Shi, JG Crump… - Proceedings of the …, 2023 - europepmc.org
Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …