Cyclooxygenase (COX) is proposed to regulate cerebral blood flow (CBF); however,
accurate regional contributions of COX are relatively unknown at baseline and particularly …

Aim The role of reactive oxygen species (ROS) in human cerebral blood flow (CBF) during
hypoxia is largely unknown. Additionally, it is unknown whether ROS interact with …

Greater cerebral artery vasodilation mediated by cyclooxygenase (COX) in female animals
is unexplored in humans. We hypothesized that young, healthy women would exhibit greater …

Cyclooxygenase (COX) is a prostanoid-synthesizing enzyme present in 2 isoforms: COX-1
and COX-2. Although it has long been hypothesized that prostanoids participate in …

The contribution of vasodilator cyclooxygenase (COX) metabolites to the maintenance of the
cerebrocortical blood flow (CBF) has been studied under physiological conditions and in …

Cyclooxygenase-1 (COX-1), a rate-limiting enzyme in the synthesis of prostanoids, is
involved in selected vasodilatatory responses of the cerebral circulation. Cyclooxygenase-1 …

Key points Cerebral blood flow increases during hypercapnia and decreases during
hypocapnia; it is unknown if vasomotion of the internal carotid artery is implicated in these …

Functional hyperemia, the brain's capability to alter microvascular blood flow in response to
the metabolic demands of active neurons, is essential for sustained mammalian brain …

We determined whether up to 24 h of ischemia could induce the expression of
cyclooxygenase-2 (COX-2) in the brain of nonhuman primates. Randomized animals were …

To investigate the role of cyclooxygenase-2 (COX-2) in the cerebrovascular coupling,
hemodynamic and neuronal responses to forepaw stimulation were measured in α …