This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of
cAMP‐regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

cAMP‐mediated signaling pathways regulate a multitude of important biological processes
under both physiological and pathological conditions, including diabetes, heart failure and …

It has now been over 10 years since efforts to completely understand the signalling actions
of cAMP (3′‐5′‐cyclic adenosine monophosphate) led to the discovery of exchange …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

Epac2, a guanine nucleotide exchange factor, regulates a wide variety of intracellular
processes in response to second messenger cAMP. In this study, we have used peptide …

The identification of 2′-O-methyl substituted adenosine-3′, 5′-cyclic monophosphate
(cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide …

Second messenger cAMP regulates many cellular functions through its effectors, such as
cAMP-dependent protein kinase (PKA) and Epac (exchange proteins directly activated by …

The cAMP-binding protein Epac is a therapeutic target for the treatment of various diseases
such as cardiac hypertrophy and tumor invasion. This points out the importance to develop …