Long non-coding RNAs in nervous system function and disease

IA Qureshi, JS Mattick, MF Mehler - Brain research, 2010 - Elsevier
Central nervous system (CNS) development, homeostasis, stress responses, and plasticity
are all mediated by epigenetic mechanisms that modulate gene expression and promote …

[HTML][HTML] Regulatory roles of long non-coding RNAs in the central nervous system and associated neurodegenerative diseases

Z Quan, D Zheng, H Qing - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Accumulating studies have revealed that the human genome encodes tens of thousands of
long non-coding RNAs (lncRNAs), which participate in multiple biological networks …

Long non-coding RNA (lncRNA) roles in cell biology, neurodevelopment and neurological disorders

V Aliperti, J Skonieczna, A Cerase - Non-coding RNA, 2021 - mdpi.com
Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …

Forging our understanding of lncRNAs in the brain

RE Andersen, DA Lim - Cell and tissue research, 2018 - Springer
During both development and adulthood, the human brain expresses many thousands of
long noncoding RNAs (lncRNAs), and aberrant lncRNA expression has been associated …

[HTML][HTML] The role of long noncoding RNAs in central nervous system and neurodegenerative diseases

CW Wei, T Luo, SS Zou, AS Wu - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a
transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate …

[HTML][HTML] Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

BS Clark, S Blackshaw - Frontiers in genetics, 2014 - frontiersin.org
Comprehensive analysis of the mammalian transcriptome has revealed that long non-
coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years …

Molecular landscape of long noncoding RNAs in brain disorders

S Yang, KH Lim, SH Kim, JY Joo - Molecular psychiatry, 2021 - nature.com
According to current paradigms, various risk factors, such as genetic mutations, oxidative
stress, neural network dysfunction, and abnormal protein degradation, contribute to the …

Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function

JL Knauss, T Sun - Neuroscience, 2013 - Elsevier
Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that
regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels …

Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases

P Wu, X Zuo, H Deng, X Liu, L Liu, A Ji - Brain research bulletin, 2013 - Elsevier
Long noncoding RNAs (lncRNAs) have been attracting immense research interest, while
only a handful of lncRNAs have been characterized thoroughly. Their involvement in the …

[HTML][HTML] Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy

IA Qureshi, MF Mehler - Neurotherapeutics, 2013 - Elsevier
The human genome encodes tens of thousands of long non-coding RNAs (lncRNAs), a
novel and important class of genes. Our knowledge of lncRNAs has grown exponentially …