Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

Stress-induced glucocorticoid hormones support coping with and adaptation to different
stressors. They act to modulate gene expression in a tissue and stressor-specific manner …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Glucocorticoid hormones play a pivotal role in the response to stressful challenges. The
surge in glucocorticoid hormone secretion after stress needs to be tightly controlled with …

All living organisms have developed a highly conserved and regulatory system, the stress
system, to cope with a broad spectrum of stressful stimuli that threaten, or are perceived as …

Following the discovery of glucocorticoid receptors in the hippocampus and other brain
regions, research has focused on understanding the effects of glucocorticoids in the brain …

Successful coping with stressful events involves adaptive and cognitive processes in the
brain that make the individual more resilient to similar stressors in the future. Stressful events …

Depression is a serious psychiatric disorder that effects at least 350 million people
worldwide today. Dysregulation of the hypothalamic-pituitary-adrenal axis (HPAA) is a …

Psychosocial stress triggers a set of behavioral, neural, hormonal, and molecular responses
that can be a driving force for survival when adaptive and time-limited, but may also …

BACKGROUND: Chronic stressors are known to increase vulnerability to medical illness, but
the mechanisms underlying this phenomenon are poorly understood. METHODS: To identify …