In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …

DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …

Abstract DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …

De novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A …

DNMT3A encodes an enzyme that carries out de novo DNA methylation, which is essential
for the acquisition of cellular identity and specialized functions during cellular differentiation …

The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …

DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is
frequently mutated in human hematologic malignancies. We have previously shown that …