Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells
can be generated to mimic embryogenesis in vitro. However, the assembly system and …

The difficulty of studying post-implantation development in mammals has sparked a flurry of
activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent …

Embryonic stem cells can be incorporated into the developing embryo and its germ line, but,
when cultured alone, their ability to generate embryonic structures is restricted. They can …

Mammalian blastocysts comprise three distinct cell lineages essential for development
beyond implantation: the pluripotent epiblast, which generates the future embryo, and …

Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …

Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass,
the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS) …

Embryonic stem (ES) cells are typically derived from the inner cell mass of the
preimplantation blastocyst and can both self-renew and differentiate into all the cells and …

The murine embryonic–trophoblast–extra-embryonic endoderm (ETX) model is an
integrated stem cell–based model to study early postimplantation development. It is based …

A single mouse blastomere from an embryo until the 8-cell stage can generate an entire
blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …