DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

DNA methylation is one of the main epigenetic mechanisms in cancer development and
progression. Aberrant DNA methylation of CpG islands within promoter regions contributes …

The cancer epigenome exhibits global loss of DNA methylation, which contributes to
genomic instability and aberrant gene expression by mechanisms that are yet to be fully …

Long non-coding RNAs (lncRNAs) are being discovered as a novel family of regulators of
gene expression at the epigenetic level. Emerging lines of evidence demonstrate that …

RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds
of RNA modifications have been identified. They are widely distributed in messenger RNA …

Long non-coding RNAs have emerged as highly versatile players in the regulation of gene
expression in development and human disease, particularly cancer. Hundreds of lncRNAs …

Empowered by recent advances of sequencing techniques, transcriptome-wide studies have
characterized over 150 different types of post-transcriptional chemical modifications of RNA …