Neonatal encephalopathy (NE) continues to have a major impact on newborn survival and
neurodevelopmental outcomes worldwide. In high-income settings, therapeutic hypothermia …

In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

Neonatal encephalopathy after perinatal hypoxic-ischemic insult is a major contributor to
global child mortality and morbidity. Brain injury in term infants in response to hypoxic …

There is increasing evidence that infants with mild neonatal encephalopathy (NE) have
significant risks of mortality, brain injury and adverse neurodevelopmental outcomes. In the …

In randomized trials, therapeutic hypothermia (TH) is associated with reduced prevalence of
the composite outcome mortality or neurodevelopmental morbidity in infants with neonatal …

Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-
severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging and …

Infants with moderate to severe neonatal encephalopathy (NE) benefit significantly from
therapeutic hypothermia, with reduced risk of death or disability. However, the need for …

This review discusses an approach to determining the cause of neonatal encephalopathy,
as well as current evidence on resuscitation and subsequent management of hypoxic …