Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors
G Zardo, MI Tiirikainen, C Hong, A Misra… - Nature …, 2002 - nature.com
Aberrant methylation of CpG islands and genomic deletion are two predominant
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns
JF Costello, MC Frühwald, DJ Smiraglia, LJ Rush… - Nature …, 2000 - nature.com
CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …
Evidence for an instructive mechanism of de novo methylation in cancer cells
I Keshet, Y Schlesinger, S Farkash, E Rand, M Hecht… - Nature …, 2006 - nature.com
DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
Predicting aberrant CpG island methylation
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …
[HTML][HTML] DNA motifs associated with aberrant CpG island methylation
Epigenetic silencing involving the aberrant methylation of promoter region CpG islands is
widely recognized as a tumor suppressor silencing mechanism in cancer. However, the …
widely recognized as a tumor suppressor silencing mechanism in cancer. However, the …
Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
ST Lee, JL Wiemels - Nucleic acids research, 2016 - academic.oup.com
The epigenetic landscape of cancer includes both focal hypermethylation and broader
hypomethylation in a genome-wide manner. By means of a comprehensive genomic …
hypomethylation in a genome-wide manner. By means of a comprehensive genomic …
[HTML][HTML] Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
Background One of the most provocative recent observations in cancer epigenetics is the
discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer …
discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer …
Genomic insights into cancer-associated aberrant CpG island hypermethylation
Carcinogenesis is thought to occur through a combination of mutational and epimutational
events that disrupt key pathways regulating cellular growth and division. The DNA …
events that disrupt key pathways regulating cellular growth and division. The DNA …
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
of methyltransferases or demethylases, yet discordant methylation patterns have also been …